N -Methyl-d-aspartate receptor (NMDAR) independent maintenance of inflammatory pain
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چکیده
منابع مشابه
Combined Therapy for Anti-N-methyl D-aspartate Receptor Encephalitis
Background Anti-N-methyl- d-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune neurological disorder that usually occurs as a paraneoplastic syndrome and is particularly associated with ovarian teratoma. Standard therapy for severe cases is not established and the prognosis in patients who do not respond to first-line treatment is poor. Case Report An 11-year-old boy complained ps...
متن کاملThe Role of the N-Methyl-D-Aspartate Receptor (NMDAR) – NR2b Subunit in Female Reproductive Aging
The loss of reproductive capacity during aging involves changes in the neural regulation of the hypothalamic gonadotropin-releasing hormone (GnRH) neurons controlling reproduction. This neuronal circuitry includes glutamatergic receptors on GnRH neurons. Previously, the Gore lab reported an increase in the expression of the NR2b subunit protein of the NMDA receptor on GnRH neurons in middle-age...
متن کاملAnti-n-Methyl-d-Aspartate-Receptor (NMDAR) Encephalitis in Association with Ovarian Teratoma
Anti-N-methyl-D-aspartate-Receptor (NMDAR) encephalitis is an autoimmune disorder with a multifaceted presentation that involves memory deficits, psychiatric symptoms, and autonomic instability. This case report describes the classic presentation of Anti-NMDAR encephalitis and highlights its association with ovarian teratomas. We present a 26 -year-old female who came in with new onset seizures...
متن کاملAcid tests of N-methyl-D-aspartate receptor gating basics.
In this issue of Molecular Pharmacology, Low et al. (2003) delve into the mechanisms by which pH modulates the glutamate receptor subtype specifically activated by N–methylD-aspartate (NMDA). Based on a combination of scanning mutagenesis, patch clamp physiology, and molecular modeling, the authors conclude that amino acids involved in NMDA receptor modulation by protons are clustered in region...
متن کاملInteraction of aquaporin 4 and N-methyl-D-aspartate NMDA receptor 1 in traumatic brain injury of rats
Objective(s): -methyl-D-aspartate NMDA receptor (NMDAR) and aquaporin 4 (AQP4) are involved in the molecular cascade of edema after traumatic brain injury (TBI) and are potential targets of studies in pharmacology and medicine. However, their association and interactions are still unknown.Materials and Methods: We established a rat TBI model in this study. The cellular distribution patterns of ...
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ژورنال
عنوان ژورنال: Pain
سال: 2010
ISSN: 0304-3959
DOI: 10.1016/j.pain.2009.11.003